Research on whether NSAIDs contribute to IBD symptoms is conflicting, creating a controversy on their use among gastroenterologists. For the class of drugs called COX-2 inhibitors, there is currently not a lot of evidence in its effects on people with IBD. Some research shows that NSAIDs may affect only a certain percentage of people with IBD, but it's impossible to know who is going to be affected and who is not. It's been speculated that using a COX-2 inhibitor, rather than a drug that is both a COX-1 and a COX-2 inhibitor, might be used with caution in those whose IBD was in remission.
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