I get 2, 4 and 5 and I’m completely natural. I have had people accuse me of taking steroids many times and it pissed me off. It gets me to the point where I want to take steroids just so that I can say “Now this is me on steroids fckers!”. Lol. But nah I get a lot of acne outbreaks naturally and I have had many stretch marks as well as abnormally fast muscle gains. I’m a very lean person and when I stop working out I’m capable of drastically going from jacked to skinny as heck. When I start back up again I blow up quick. Another thing I’ve noticed is my pumps are naturally a lot more intense then the average lifter. Like my shoulders blow up like bowling balls and veins and shreds show up all over them along with my arm’s and chest. I’ve had a tone of people accuse me of taking steroids because of these factors. I also had a relative hug me once and say I was jacked and as solid as steal. He said only steroids do that. (He took steroids in the past) But it is to my understanding that muscle is solid… or at least a lot more solid than fat. At the time I was taking creatine and l-arginine with citrilline malate (which is a precursor to arginine) and a lot of BCAA’s.
Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.
Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen . [ Ref ]