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Por lo general, un técnico extraerá la sangre a partir de una vena, después de limpiar la superficie de la piel con un antiséptico y de colocar una goma elástica (que hará de torniquete) en la parte superior del brazo para ejercer presión y conseguir que las venas se hinchen y se llenen de sangre. A continuación, se inserta una aguja en el interior de una vena (generalmente en la cara interna del codo o en el dorso de la mano) y la sangre se extrae y se recoge en un vial o en una jeringuilla.