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This can be countered to an extent. You can increase the dosage towards the middle and later parts of taking it to increase the positive effects. You can also take a period of time away from the drug, cycling off for a bit to give your body time to recover before getting back to it again. Be aware that the more you take a day, the less results you will get added to through the additional dosage. So for example, taking 50mg a day adds a lot. Adding 50mg a day improves the results, but not by much. Adding 50mg more for 150mg a day adds slightly more, but it is typically not worth the negative side effects to your health for only marginal improvements. Studies conducted on the drug helps to back up this assertion, postulating that 100mgs/day is perfect for Anadrol cycling.
There is limited information available on the pharmacokinetics of oxymetholone.  It appears to be well-absorbed with oral administration .  Oxymetholone has very low affinity for human serum sex hormone-binding globulin (SHBG), less than 5% of that of testosterone and less than 1% of that of DHT.  The drug is metabolized in the liver by oxidation at the C2 position, reduction at the C3 position, hydroxylation at the C17 position, and conjugation .   The C2 hydroxymethylene group of oxymetholone can be cleaved to form mestanolone (17α-methyl-DHT), which may contribute to the effects of oxymetholone.  The elimination half-life of oxymetholone is unknown.  Oxymetholone and its metabolites are eliminated in the urine .